Smartbax nominated for Falling Walls award

Start-up dedicated to developing new antibiotics

The foundations for this innovation were laid in the laboratories at TUM. “It was pure basic research to begin with,” emphasizes Sieber. “We tested hundreds of different agents in cultures with Staphylococcus aureus and came across a molecule that kills the bacteria off very effectively. We then examined the mode of action of this molecule, which we call PK150.” The results showed that PK150 has a fundamentally different mode of action to conventional antibiotics. Instead of suppressing biochemical processes, PK150 stimulates the excretion of proteins in the cell wall. Key enzymes are discharged from the cells and, in effect, the cell walls begin to digest themselves. At the same time, the molecule blocks the metabolic system, which means the cell cannot store any more energy and dies. Due to this dual mode of action, it is exceptionally unlikely that bacteria will develop mutations with resistances to this agent.

“Once it became clear that this molecule is a promising candidate for the development of a new antibiotic, we both knew we wanted to develop the agent,” recalls Sieber. “It is suitable for combating Staphylococcus aureus and other multidrug-resistant bacteria that are gram-positive, which means they have a single layer cell wall.” TUM applied for a patent for the structure of the optimized molecule for the first time in 2017 while Sieber and Macsics began the search for investors. Even during the coronavirus pandemic, the two researchers secured the support of the Boehringer Ingelheim Venture Fund following a virtual pitch.

Soon after, in 2021, the duo founded smartbax – one of the first start-ups accepted into the new TUM Venture Lab ChemSPACE. Each TUM Venture Lab specializes in a significant technological field. Start-up teams benefit from specific technical infrastructure, tailored training programs, expertise in the relevant market and global industry networks. “The opportunity to use the infrastructure and laboratory spaces at the Venture Lab was immensely helpful for us as we took our first steps as an independent company,” says Macsics, who became the start-up’s CEO after completing his doctorate. “There’s also the Venture Lab’s network, which continuously helps us to make new contacts.”

Smartbax now has three permanent employees, with Stephan Sieber assisting as a scientific consultant. In addition to developing the active agent, the company is working on other strategies to combat drug-resistant bacteria. It aims to have its first drug candidates ready for clinical trials within a few years.

The Falling Walls jury identified the team’s work as one of the most potentially significant breakthroughs of the year. The eponymous charitable foundation hosts the Falling Walls Science Summit on November 9 each year. The event marks the fall of the Berlin Wall and strives to highlight the walls torn down by science to a wide audience. The summit is one of the most important events linking research with wider society and is also a key date in the scientific calendar.

Falling Walls names Science Breakthroughs of the Year in five fields of research and in the Science Start-Up category. Smartbax has been nominated along with 24 other start-ups from Europe, the Americas, Asia and Australia.